Quipazine and light have similar effects on c-fos induction in the rat suprachiasmatic nucleus

被引：27

作者：

Moyer, RW

Kennaway, DJ

Ferguson, SA

Dijstelbloem, YP

机构：

[1] Dept. of Obstetrics and Gynaecology, University of Adelaide, Medical School, Adelaide, SA 5005, Frome Road

来源：

BRAIN RESEARCH | 1997年 / 765卷 / 02期

基金：

英国医学研究理事会;

关键词：

serotonin; quipazine; suprachiasmatic nucleus; circadian rhythm; fos;

D O I：

10.1016/S0006-8993(97)00685-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of the serotonin agonist, quipazine, on the induction of c-fos in the suprachiasmatic nucleus of the rat was examined at different times of the 24 h cycle. Quipazine administered at night induced Fos production in a dose dependent manner (1, 3, 10, 30 mu mol/kg) in the ventrolateral portion of the suprachiasmatic nucleus at ZT18. Administration of the highest dose at other times resulted in c-fos induction at ZT15 but not at other times of the day or subjective day examined (CT6 and ZT12). When compared to the effects of light pulses (2 lux/1 min), quipazine only caused c-fos induction at times when light caused induction. Our results support a role of serotonergic pathways in the transmission or modulation of photic information from the retina to the suprachiasmatic nucleus of the rat. (C) 1997 Elsevier Science B.V.

引用

页码：337 / 342

页数：6

共 37 条

[1] EFFECTS OF DESTRUCTION OF THE SUPRACHIASMATIC NUCLEI ON THE CIRCADIAN-RHYTHMS IN PLASMA-CORTICOSTERONE, BODY-TEMPERATURE, FEEDING AND PLASMA THYROTROPIN [J].