Aspergillus galactomannan antigen in the cerebrospinal fluid of bone marrow transplant recipients with probable cerebral aspergillosis

被引：106

作者：

Viscoli, C

Machetti, M

Gazzola, P

De Maria, A

Paola, D

Van Lint, MT

Gualandi, F

Truini, M

机构：

[1] Univ Genoa, Dipartimento Oncol Biol & Genet, I-16132 Genoa, Italy

[2] Univ Genoa, Dipartimento Sci Neurol & Vis, I-16132 Genoa, Italy

[3] Univ Genoa, Dipartimento Med Interna, I-16132 Genoa, Italy

[4] Univ Genoa, Dipartimento Med Sperimentale, I-16132 Genoa, Italy

[5] Univ Genoa, Dipartimento Diagnost Lab Anat Patol & Med Legale, I-16132 Genoa, Italy

[6] Osped San Martino Genova, Genoa, Italy

[7] Univ Genoa, Ist Nazl Ric Canc, I-16132 Genoa, Italy

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2002年 / 40卷 / 04期

关键词：

D O I：

10.1128/JCM.40.4.1496-1499.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Aspergillus galactomannan test was performed on cerebrospinal fluid and serum samples from 5 patients with probable cerebral aspergillosis and from 16 control patients. Cerebrospinal fluid galactomannan levels were significantly higher in aspergillosis patients, and most galactomannan was produced intrathecally. Comparison of serum galactomannan values in pulmonary and cerebral aspergillosis patients showed significant overlapping. Detection of Aspergillus galactomannan in cerebrospinal fluid may be diagnostic of cerebral aspergillosis.

引用

收藏

页码：1496 / 1499

页数：4

相关论文

共 18 条

[1] Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: An international consensus [J].

Ascioglu, S ;

Rex, JH ;

de Pauw, B ;

Bennett, JE ;

Bille, J ;

Crokaert, F ;

Denning, DW ;

Donnelly, JP ;

Edwards, JE ;

Erjavec, Z ;

Fiere, D ;

Lortholary, O ;

Maertens, J ;

Meis, JF ;

Patterson, TF ;

Ritter, J ;

Selleslag, D ;

Shah, PM ;

Stevens, DA ;

Walsh, TJ .

CLINICAL INFECTIOUS DISEASES, 2002, 34 (01) :7-14

[2]

Denning DW, 2000, LANCET, V355, P423, DOI 10.1016/S0140-6736(00)82003-6

[3] Invasive aspergillosis [J].

Denning, DW .

CLINICAL INFECTIOUS DISEASES, 1998, 26 (04) :781-803

[4] Early diagnosis of central nervous system aspergillosis using polymerase chain reaction, latex agglutination test, and enzyme-linked immunosorbent assay [J].

Kami, M ;

Ogawa, S ;

Kanda, Y ;

Tanaka, Y ;

Machida, U ;

Matsumura, T ;

Sakamaki, H ;

Hirai, H .

BRITISH JOURNAL OF HAEMATOLOGY, 1999, 106 (02) :536-537

[5] NEW CAUSE FOR FALSE-POSITIVE RESULTS WITH THE PASTOREX ASPERGILLUS ANTIGEN LATEX AGGLUTINATION-TEST [J].

KAPPE, R ;

SCHULZEBERGE, A .

JOURNAL OF CLINICAL MICROBIOLOGY, 1993, 31 (09) :2489-2490

[6]

LATGE JP, 1994, INFECT IMMUN, V62, P5424

[7] Comparison of an enzyme immunoassay and a latex agglutination system for the diagnosis of invasive aspergillosis in bone marrow transplant recipients [J].

Machetti, M ;

Feasi, M ;

Mordini, N ;

Van Lint, MT ;

Bacigalupo, A ;

Latgé, JP ;

Sarfati, J ;

Viscoli, C .

BONE MARROW TRANSPLANTATION, 1998, 21 (09) :917-921

[8]

Machetti M, 2000, Transpl Infect Dis, V2, P140, DOI 10.1034/j.1399-3062.2000.020307.x

[9] Autopsy-Controlled prospective evaluation of serial screening for circulating galactomannan by a sandwich enzyme-linked immunosorbent assay for hematological patients at risk for invasive aspergillosis [J].

Maertens, J ;

Verhaegen, J ;

Demuynck, H ;

Brock, P ;

Verhoef, G ;

Vandenberghe, P ;

van Eldere, J ;

Verbist, L ;

Boogaerts, M .

JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (10) :3223-3228

[10] Localization of aspergillosis to the central nervous system among patients with acute leukemia: Report of 14 cases [J].

Pagano, L ;

Ricci, P ;

Montillo, M ;

Cenacchi, A ;

Nosari, A ;

Tonso, A ;

Cudillo, L ;

Chierichini, A ;

Savignano, C ;

Buelli, M ;

Melillo, L ;

LaBarbera, EO ;

Sica, S ;

Hohaus, S ;

Bonini, A ;

Bucaneve, G ;

DelFavero, A .

CLINICAL INFECTIOUS DISEASES, 1996, 23 (03) :628-630