NMDA receptor-dependent and -independent long-term depression in the CA1 region of the adult rat hippocampus in vivo

被引：55

作者：

Kemp, N ^{[1
]}

Bashir, ZI ^{[1
]}

机构：

[1] UNIV BRISTOL,SCH MED SCI,DEPT ANAT,BRISTOL BS8 1TD,AVON,ENGLAND

来源：

NEUROPHARMACOLOGY | 1997年 / 36卷 / 03期

基金：

英国惠康基金;

关键词：

long-term depression (LTD); CA1; hippocampus; NMDA; plasticity;

D O I：

10.1016/S0028-3908(96)90015-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have investigated different stimulus parameters in an attempt to induce long-term depression (LTD) in the CA1 region of adult rat hippocampus in vitro. Whereas 900 stimuli delivered at 1 Hz failed to induce LTD, 900 stimuli when delivered as 450 pairs (50 msec inter-stimulus interval) at 1 Hz induced significant and stable N-methyl-D-aspartate (NMDA) receptor-dependent LTD. However, 900 paired stimuli at 1 Hz induced LTD which was only partly blocked by the NMDA receptor antagonist, D-2-amino-5-phosphonopentanoate (AP5). (C) 1997 Elsevier Science Ltd.

引用

页码：397 / 399

页数：3

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