Atypical kinetic profiles in drug metabolism reactions

被引：225

作者：

Hutzler, JM ^{[1
]}

Tracy, TS ^{[1
]}

机构：

[1] W Virginia Univ, Sch Pharm, Dept Basic Pharmaceut Sci, Morgantown, WV 26506 USA

来源：

DRUG METABOLISM AND DISPOSITION | 2002年 / 30卷 / 04期

关键词：

D O I：

10.1124/dmd.30.4.355

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：355 / 362

页数：8

共 62 条

[1] DIAZEPAM METABOLISM BY HUMAN LIVER-MICROSOMES IS MEDIATED BY BOTH S-MEPHENYTOIN HYDROXYLASE AND CYP3A ISOFORMS [J].

ANDERSSON, T ;

MINERS, JO ;

VERONESE, ME ;

BIRKETT, DJ .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1994, 38 (02) :131-137

[2] Allosteric behavior in cytochrome P450-dependent in vitro drug-drug interactions: A prospective based on conformational dynamics [J].

Atkins, WM ;

Wang, RW ;

Lu, AYH .

CHEMICAL RESEARCH IN TOXICOLOGY, 2001, 14 (04) :338-347

[3] Kinetic studies of hepatocyte UDP-glucuronosyltransferase: Evidence of an allosteric enzyme [J].

Bruni, S ;

Chang, TMS .

ARTIFICIAL CELLS BLOOD SUBSTITUTES AND IMMOBILIZATION BIOTECHNOLOGY, 1999, 27 (04) :343-356

[4]

Domanski TL, 2000, J PHARMACOL EXP THER, V293, P585

[5] Analysis of four residues within substrate recognition site 4 of human cytochrome p450 3A4:: Role in steroid hydroxylase activity and α-naphthoflavone stimulation [J].

Domanski, TL ;

Liu, JP ;

Harlow, GR ;

Halpert, JR .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1998, 350 (02) :223-232

[6]

Ekins S, 1998, J PHARMACOL EXP THER, V286, P1253

[7]

Ekins S, 1998, INT J CLIN PHARM TH, V36, P642

[8]

Fisher MB, 2000, DRUG METAB DISPOS, V28, P560

[9] Interaction of apo-cytochrome b5 with cytochromes P4503A4 and P45017A:: Relevance of heme transfer reactions [J].

Guryev, OL ;

Gilep, AA ;

Usanov, SA ;

Estabrook, RW .

BIOCHEMISTRY, 2001, 40 (16) :5018-5031

[10] Analysis of human cytochrome P450 3A4 cooperativity: Construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kinetics [J].

Harlow, GR ;

Halpert, JR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (12) :6636-6641

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