HBV Induced HCC: Major Risk Factors from Genetic to Molecular Level

被引：56

作者：

Ayub, Ambreen ^{[1
]}

Ashfaq, Usman Ali ^{[1
]}

Haque, Asma ^{[1
]}

机构：

[1] Govt Coll Univ Faisalabad, Dept Bioinformat & Biotechnol, Faisalabad 38000, Pakistan

来源：

BIOMED RESEARCH INTERNATIONAL | 2013年 / 2013卷

关键词：

HEPATITIS-B-VIRUS; HUMAN HEPATOCELLULAR-CARCINOMA; METABOLIC SYNDROME INCREASES; CHRONIC LIVER-DISEASE; X-PROTEIN; GROWTH-FACTOR; OXIDATIVE STRESS; SURFACE-ANTIGEN; CELL-CYCLE; PROMOTER POLYMORPHISMS;

D O I：

10.1155/2013/810461

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Hepatocellular carcinoma (HCC) is a deadly and emerging disease leading to death in Asian countries. High hepatitis B virus (HBV) load and chronic hepatitis B (CHB) infection increase the risk of developing HCC. HBV is a DNA virus that can integrate DNA into host genome thereby increase the yield of transactivator protein HBxAg that may deregulate many pathways involving in metabolism of cells. Several monogenic and polygenic risk factors are also involved in HCC development. This review summarizes the mechanism involved in HCC development and discusses some promising therapies to make HCC curative.

引用

页数：14

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