The stereoselective preparation of beta-hydroxy esters using a yeast reduction in an organic solvent

被引：60

作者：

Medson, C ^{[1
]}

Smallridge, AJ ^{[1
]}

Trewhella, MA ^{[1
]}

机构：

[1] VICTORIA UNIV TECHNOL,DEPT BIOL & CHEM,MELBOURNE,VIC 8001,AUSTRALIA

来源：

TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 07期

关键词：

D O I：

10.1016/S0957-4166(97)00050-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A range of (S)-beta-hydroxy esters has been prepared in high yield (56-96%) and with very high enantioselectivity (>94%) using a yeast mediated reduction in light petroleum. It was found that the ester functionality had a marked effect on both the isolated yield and the quantity of yeast required to effect complete reduction. (C) 1997 Elsevier Science Ltd.

引用

页码：1049 / 1054

页数：6

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