Effect of pulsatile and nonpulsatile assist on heart and kidney microcirculation with cardiogenic shock

被引：25

作者：

Nakata, K ^{[1
]}

Shiono, M ^{[1
]}

Orime, Y ^{[1
]}

Hata, M ^{[1
]}

Sezai, A ^{[1
]}

Saitoh, T ^{[1
]}

Sezai, Y ^{[1
]}

机构：

[1] NIHON UNIV,SCH MED,DEPT SURG 2,TOKYO,JAPAN

来源：

ARTIFICIAL ORGANS | 1996年 / 20卷 / 06期

关键词：

microcirculation; cardiogenic shock; pulsatile assist; nonpulsatile assist; major organ failure;

D O I：

10.1111/j.1525-1594.1996.tb04502.x

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

To estimate microcirculation of the heart and kidney in pulsatile and nonpulsatile-assisted circulation, a comparison study was done using a swine model. Acute myocardial infarction was made by ligation of the left coronary artery branches. After cardiogenic shock, animals were divided into 3 groups as follows: Group C (n = 6), no assist provided; Group NP (n = 6), assisted by a nonpulsatile pump (Bio-Medicus BP-80); Group P (n 6), supported by a pulsatile pump (Nippon Zeon). Left coronary artery flow, endocardial and epicardial regional flows, and renal cortex and medulla tissue blood flows were measured. Left coronary artery flow and endocar dial and epicardial tissue blood flows decreased in cardiogenic shock, and they recovered to the control level soon after support in both Group N and Group P. Renal medulla and cortex tissue blood flows decreased in cardiogenic shock, and these flows did not recover in either Group N or P. However, cortex blood flow in Group P did improve, but it did not improve in Group N. These results suggested that pulsatile assist was more effective than nonpulsatile assist for microcirculation after cardiogenic shock to avoid deterioration of major organ functions.

引用

页码：681 / 684

页数：4

共 7 条

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