In vitro release study of verapamil hydrochloride through sodium alginate interpenetrating monolithic membranes

被引：19

作者：

Kurkuri, MD

Kulkarni, AR

Kariduraganavar, MY

Aminabhavi, TM ^{[1
]}

机构：

[1] Karnatak Univ, Dept Chem, Polymer Res Grp, Dharwad 580003, Karnataka, India

[2] KLEs Coll Pharm, Vijayanagar 580031, Hubli, India

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 2001年 / 27卷 / 10期

关键词：

interpenetrating network; sodium alginate; transdermal matrix; verapamil hydrochloride;

D O I：

10.1081/DDC-100108373

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Polymeric sodium alginate interpenetrating network membranes containing verapamil hydrochloride were fabricated for transdermal application. The membranes were evaluated for their physical properties, weight and thickness uniformity, water vapor transmission, as well as drug content uniformity. All the thin patches were transparent, smooth, and flexible. The drug-loaded membranes were analyzed by X-ray diffraction to understand the drug polymorphism inside the membrane. The transdermal patches were permeable to water vapor, indicating the permeability characteristics of the polymers. The in vitro drug release was performed in distilled water using a Keshary-Chien diffusion cell. The release data were analyzed to understand the mechanism of drug release.

引用

页码：1107 / 1114

页数：8

共 29 条

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