Expression pattern of the Tbr2 (Eomesodermin) gene during mouse and chick brain development

被引：124

作者：

Bulfone, A

Martinez, S

Marigo, V

Campanella, M

Basile, A

Quaderi, N

Gattuso, C

Rubenstein, JLR

Ballabio, A

机构：

[1] Telethon Inst Genet & Med, TIGEM, I-20132 Milan, Italy

[2] Univ Murcia, Dept Morphol Sci, Murcia 30071, Spain

[3] Univ Calif San Francisco, Dept Psychiat, Nina Ireland Lab Dev Neurobiol, San Francisco, CA 94143 USA

来源：

MECHANISMS OF DEVELOPMENT | 1999年 / 84卷 / 1-2期

关键词：

T-box genes; eomesodermin; Tbr1; Tbr2; mouse embryo; chick embryo; development; expression pattern; forebrain; telencephalon; cerebral cortex; cerebellum; eye; limb;

D O I：

10.1016/S0925-4773(99)00053-2

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The members of the T-box gene family share a highly conserved DNA binding domain named the T-domain, and important developmental functions. Here we report the cloning of chicken Tbr1 and of murine and chicken Tbr2 (orthologs of the Xenopus eomesodermin gene), the mapping of the murine Tbr2 to chromosome 9, and their pattern of expression during mouse and chick embryogenesis. Both Tbr 1 and 2 have a restricted and conserved domain of expression in the telencephalic pallium of the two species. Chick Tbr2 has a specific and dynamic expression in the gastrulating embryo. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：133 / 138

页数：6

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