What has been learned about the cardiovascular effects of matrix metalloproteinases from mouse models?

被引:56
作者
Janssens, S
Lijnen, HR
机构
[1] Univ Leuven VIB, Dept Cardiol, Ctr Transgene Technol & Gene Therapy, Louvain, Belgium
[2] Katholieke Univ Leuven, Ctr Mol & Vasc Biol, Louvain, Belgium
关键词
matrix metalloproteinases; transgenic mice; left ventricular remodelling; myocardial infarction; atherosclerosis; vascular injury;
D O I
10.1016/j.cardiores.2005.12.010
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes responsible for extracellular protein degradation in the cardiovascular system. Originally known to play pivotal roles in tissue morphogenesis and wound healing, they have been shown to participate in the complex remodeling processes in blood vessels and the myocardium. The biological activity of MMPs is regulated at different levels: (1) gene expression, (2) activation of precursor proenzyme forms by other MMPs or non-MMP proteins, including thrombin and plasmin, (3) complex formation with surface and extracellular matrix (ECM) components and (4) inhibition by endogenous tissue inhibitors of MMPs, the TIMPs. Murine models with gain or loss of gene function of different MMPs and TIMPS have provided a wealth of experimental data on their critical role in pathological conditions ranging from atherosclerosis, vascular injury and restenosis to left ventricular function and structural remodeling following chronic pressure and volume overload and ischemia-reperfusion injury. (c) 2005 European Society of Cardiology. Published by Elsevier B.V.
引用
收藏
页码:585 / 594
页数:10
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