Hypoxia induces pivotal tumor angiogenesis control factors including p53, vascular endothelial growth factor and the NFkB-dependent inducible nitric oxide synthase and cyclooxygenase-2

被引：31

作者：

Chiarugi, V

Magnelli, L

Chiarugi, A

Gallo, O

机构：

[1] Univ Florence, Dept Pathol & Expt Oncol, Mol Biol Lab, I-50134 Florence, Italy

[2] Univ Florence, Azienda Osped Careggi, Inst Otolaryngol Head & Neck Surg, Florence, Italy

[3] Univ Florence, Dept Pharmacol, Florence, Italy

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 1999年 / 125卷 / 8-9期

关键词：

hypoxia; P53; hypoxia inducible factor (HIF); inducible nitric oxide synthase (iNOS); cyclooxygenase-2 (COX-2);

D O I：

10.1007/s004320050312

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：525 / 528

页数：4

共 26 条

[1] P53 and vascular endothelial growth factor regulate tumor growth of NOS2-expressing human carcinoma cells
Ambs, S
Merriam, WG
Ogunfusika, MO
Bennett, WP
Ishibe, N
Hussain, SP
Tzeng, EE
Geller, DA
Billiar, TR
Harris, CC
[J]. NATURE MEDICINE, 1998, 4 (12) : 1371 - 1376
[2] Stabilization of wild-type p53 by hypoxia-inducible factor 1α
An, WG
Kanekal, M
Simon, MC
Maltepe, E
Blagosklonny, MV
Neckers, LM
[J]. NATURE, 1998, 392 (6674) : 405 - 408
[3] The molecular basis of the hypoxia response pathway: Tumour hypoxia as a therapy target
Blancher, C
Harris, AL
[J]. CANCER AND METASTASIS REVIEWS, 1998, 17 (02) : 187 - 194
[4] Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
Boehm, T
Folkman, J
Browder, T
OReilly, MS
[J]. NATURE, 1997, 390 (6658) : 404 - 407
[5] Role of HIF-1α or in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
Carmeliet, P
Dor, Y
Herbert, JM
Fukumura, D
Brusselmans, K
Dewerchin, M
Neeman, M
Bono, F
Abramovitch, R
Maxwell, P
Koch, CJ
Ratcliffe, P
Moons, L
Jain, RK
Collen, D
Keshet, E
[J]. NATURE, 1998, 394 (6692) : 485 - 490
[6] Chiarugi V, 1998, INT J MOL MED, V2, P715
[7] Regulation of VEGF/VPF expression in tumor cells: Consequences for tumor growth and metastasis
Claffey, KP
Robinson, GS
[J]. CANCER AND METASTASIS REVIEWS, 1996, 15 (02) : 165 - 176
[8] Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
Graeber, TG
Osmanian, C
Jacks, T
Housman, DE
Koch, CJ
Lowe, SW
Giaccia, AJ
[J]. NATURE, 1996, 379 (6560) : 88 - 91
[9] The hypoxic response: Huffing and HIFing
Guillemin, K
Krasnow, MA
[J]. CELL, 1997, 89 (01) : 9 - 12
[10] VASCULAR ENDOTHELIAL-CELL GROWTH-FACTOR PROMOTES TYROSINE PHOSPHORYLATION OF MEDIATORS OF SIGNAL-TRANSDUCTION THAT CONTAIN SH2 DOMAINS - ASSOCIATION WITH ENDOTHELIAL-CELL PROLIFERATION
GUO, DQ
JIA, Q
SONG, HY
WARREN, RS
DONNER, DB
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (12) : 6729 - 6733

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