Epitaxial relationships between cholesterol crystals and mineral phases: Implication for human disease

被引：22

作者：

Frincu, MC ^{[1
]}

Sharpe, RE ^{[1
]}

Swift, JA ^{[1
]}

机构：

[1] Georgetown Univ, Dept Chem, Washington, DC 20057 USA

来源：

CRYSTAL GROWTH & DESIGN | 2004年 / 4卷 / 02期

关键词：

D O I：

10.1021/cg034180a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Human gallstones and atherosclerotic plaques are heterogeneous materials that consist of a variety of components, including crystalline cholesterol and assorted mineral phases. EpiCalc, a modeling algorithm that uses a simple geometric lattice matching protocol, was used as a screening tool to identify those surfaces of calcium carbonate and calcium phosphate that could potentially serve as epitaxial substrates for the nucleation and growth of anhydrous cholesterol (Ch) and cholesterol monohydrate (ChM) crystals. A surprisingly large number of coincident, epitaxial relationships were identified, with the best match found between calcite (10 (1) over bar4) and ChM (001).

引用

页码：223 / 226

页数：4

共 19 条

[1] Surface characterization of cholesterol monohydrate single crystals by chemical force microscopy [J].