Estrogen and testosterone use different cellular pathways to inhibit osteoclastogenesis and bone resorption

被引：144

作者：

Michael, H

Härkönen, PL

Väänänen, HK

Hentunen, TA

机构：

[1] Univ Turku, Inst Biomed, Dept Anat, Turku 20700, Finland

[2] Lund Univ, Dept Lab Med, MAS Univ Hosp, Lund, Sweden

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2005年 / 20卷 / 12期

关键词：

estrogen; testosterone; human CD14(+) monocytes; osteoclast formation; bone resorption; estrogen receptor; androgen receptor;

D O I：

10.1359/JBMR.050803

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Using human peripheral blood CD14(+) osteoclast precursors, we show that testosterone directly inhibits osteoclast formation and bone resorption at physiological concentrations. Instead, estrogen has no direct effects, whereas its action seems to be mediated through osteoblasts by producing osteoprotegerin. Both estrogen and testosterone acts through their cognate receptors.

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收藏

页码：2224 / 2232

页数：9

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