The history of Toll-like receptors - redefining innate immunity

被引：1287

作者：

O'Neill, Luke A. J. ^{[1
]}

Golenbock, Douglas ^{[2
]}

Bowie, Andrew G. ^{[1
]}

机构：

[1] Trinity Coll Dublin, Trinity Biomed Sci Inst, Sch Biochem & Immunol, Dublin 2, Ireland

[2] Univ Massachusetts, Div Infect Dis & Immunol, Sch Med, Worcester, MA 01605 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2013年 / 13卷 / 06期

基金：

欧洲研究理事会; 爱尔兰科学基金会;

关键词：

NF-KAPPA-B; SINGLE-STRANDED RNA; DENDRITIC CELLS; CUTTING EDGE; SIGNALING PATHWAY; ADAPTER MOLECULE; STRUCTURAL BASIS; DROSOPHILA TOLL; BINDING-PROTEIN; IL-1; RECEPTOR;

D O I：

10.1038/nri3446

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The discovery of Toll-like receptors (TLRs) was an important event for immunology research and was recognized as such with the awarding of the 2011 Nobel Prize in Physiology or Medicine to Jules Hoffmann and Bruce Beutler, who, together with Ralph Steinman, the third winner of the 2011 Nobel Prize and the person who discovered the dendritic cell, were pioneers in the field of innate immunity. TLRs have a central role in immunity - in this Timeline article, we describe the landmark findings that gave rise to this important field of research.

引用

页码：453 / 460

页数：8

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