SIFTS: updated Structure Integration with Function, Taxonomy and Sequences resource allows 40-fold increase in coverage of structure-based annotations for proteins

被引：159

作者：

Dana, Jose M. ^{[1
]}

Gutmanas, Aleksandras ^{[1
]}

Tyagi, Nidhi ^{[2
]}

Qi, Guoying ^{[2
]}

O'Donovan, Claire ^{[3
]}

Martin, Maria ^{[2
]}

Velankar, Sameer ^{[1
]}

机构：

[1] EBI, Prot Data Bank Europe, EMBL, Wellcome Genome Campus, Cambridge CB10 1SD, England

[2] EBI, Prot Funct Dev, EMBL, Wellcome Genome Campus, Cambridge CB10 1SD, England

[3] EBI, Metab, European Mol Biol Lab, Wellcome Genome Campus, Cambridge CB10 1SD, England

来源：

NUCLEIC ACIDS RESEARCH | 2019年 / 47卷 / D1期

基金：

美国国家卫生研究院; 英国惠康基金; 英国生物技术与生命科学研究理事会; 英国科研创新办公室;

关键词：

DATA-BANK; DATABASE; GENE; PDBE;

D O I：

10.1093/nar/gky1114

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Structure Integration with Function, Taxonomy and Sequences resource (SIFTS; http://pdbe.org/sifts/) was established in 2002 and continues to operate as a collaboration between the Protein Data Bank in Europe (PDBe; http://pdbe.org) and the UniProt Knowledgebase (UniProtKB; http://uniprot.org). The resource is instrumental in the transfer of annotations between protein structure and protein sequence resources through provision of up-to-date residue-level mappings between entries from the PDB and from UniProtKB. SIFTS also incorporates residue-level annotations from other biological resources, currently comprising the NCBI taxonomy database, IntEnz, GO, Pfam, InterPro, SCOP, CATH, PubMed, Ensembl, Homologene and automatic Pfam domain assignments based on HMM profiles. The recently released implementation of SIFTS includes support for multiple cross-references for proteins in the PDB, allowing mappings to UniProtKB isoforms and UniRef90 cluster members. This development makes structure data in the PDB readily available to over 1.8 million UniProtKB accessions.

引用

页码：D482 / D489

页数：8

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