Anti-angiogenic activity of a homoisoflavanone from Cremastra appendiculata

被引：158

作者：

Shim, JS ^{[1
]}

Kim, JH ^{[1
]}

Lee, JY ^{[1
]}

Kim, SN ^{[1
]}

Kwon, HJ ^{[1
]}

机构：

[1] Sejong Univ, Inst Biosci, Dept Biosci & Biotechnol, Seoul 143747, South Korea

来源：

PLANTA MEDICA | 2004年 / 70卷 / 02期

关键词：

D O I：

10.1055/s-2004-815496

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

A homorisoflavanone, 5,7-diliydi-oxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one (1), was isolated from the bulb of Cremastra appendiculata (D. Don) Makino (Orchidaceae) as a potent inhibitor of angiogenesis. It inhibited basic fibroblast growth factor (bFGF)-induced in vitro angiogenesis and in vivo angiogenesis of the chorioallantoic membrane (CAM) of chick embryo without showing any toxicity.

引用

页码：171 / 173

页数：3

共 7 条

[1]

ADINOLFI M, 1987, PHYTOCHEMISTRY, V26, P285, DOI 10.1016/S0031-9422(00)81529-0

[2]

Homoisoflavanones from three South African Scilla species [J].