Dual side-reactions limit the utility of a key polymer therapeutic precursor

被引：29

作者：

Devenish, SRA

Hill, JB

Blunt, JW

Morris, JC

Munro, MHG

机构：

[1] Univ Canterbury, Dept Chem, Christchurch 1, New Zealand

[2] Univ Adelaide, Sch Chem & Phys, Adelaide, SA 5005, Australia

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 17期

关键词：

pMAOS; pHPMA; NHS ester; NMR spectroscopy; structure elucidation; chemoselectivity;

D O I：

10.1016/j.tetlet.2006.02.131

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In contrast to literature reports, the activated polyacid poly(methacryloxysuccinimide) reacts with nucleophiles to give, initially, a high proportion of ring-opened residues. This copolymer then reacts intramolecularly to form a polymer with a high fraction of glutarimide residues. These side reactions occur to such an extent as to preclude the use of poly(methacryloxysuccinimide) as a precursor to polymethacrylamides. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：2875 / 2878

页数：4

共 16 条

[1] Drug delivery systems: Entering the mainstream [J].