Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer

被引：958

作者：

Bowtell, David D. ^{[1
,2
]}

Boehm, Steffen ^{[3
]}

Ahmed, Ahmed A. ^{[4
,5
]}

Aspuria, Paul-Joseph ^{[6
]}

Bast, Robert C., Jr. ^{[7
]}

Beral, Valerie ^{[8
]}

Berek, Jonathan S. ^{[9
]}

Birrer, Michael J. ^{[10
]}

Blagden, Sarah ^{[11
]}

Bookman, Michael A. ^{[12
]}

Brenton, James D. ^{[13
]}

Chiappinelli, Katherine B. ^{[14
]}

Martins, Filipe Correia ^{[13
]}

Coukos, George ^{[15
]}

Drapkin, Ronny ^{[16
]}

Edmondson, Richard ^{[17
]}

Fotopoulou, Christina ^{[11
]}

Gabra, Hani ^{[11
]}

Galon, Jerome ^{[18
]}

Gourley, Charlie ^{[19
]}

Heong, Valerie ^{[20
]}

Huntsman, David G. ^{[21
,22
]}

Iwanicki, Marcin ^{[23
]}

Karlan, Beth Y. ^{[6
]}

Kaye, Allyson ^{[24
]}

Lengyel, Ernst ^{[25
]}

Levine, Douglas A. ^{[26
]}

Lu, Karen H. ^{[7
]}

McNeish, Iain A. ^{[27
]}

Menon, Usha ^{[28
]}

Narod, Steven A. ^{[29
]}

Nelson, Brad H. ^{[30
]}

Nephew, Kenneth P. ^{[31
,32
]}

Pharoah, Paul ^{[33
]}

Powell, Daniel J., Jr. ^{[34
]}

Ramos, Pilar ^{[35
]}

Romero, Iris L. ^{[25
]}

Scott, Clare L. ^{[20
]}

Sood, Anil K. ^{[7
]}

Stronach, Euan A. ^{[11
]}

Balkwill, Frances R. ^{[3
]}

机构：

[1] Peter MacCallum Canc Ctr, Canc Genom & Genet Program, Melbourne, Vic 8006, Australia

[2] Garvan Inst Med Res, Kinghorn Canc Ctr, Sydney, NSW 2010, Australia

[3] Queen Mary Univ London, Barts Canc Inst, London EC1M6BQ, England

[4] John Radcliffe Hosp, Dept Obstet & Gynaecol, Oxford OX3 9DS, England

[5] John Radcliffe Hosp, Weatherall Inst Mol Med, Oxford OX3 9DS, England

[6] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA

[7] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[8] Univ Oxford, Oxford OX3 7LF, England

[9] Stanford Univ, Stanford, CA 94305 USA

[10] Massachusetts Gen Hosp, Boston, MA 02114 USA

[11] Univ London Imperial Coll Sci Technol & Med, Ovarian Canc Action Res Ctr, London W12 0NN, England

[12] Arizona Oncol, Tucson, AZ 85711 USA

[13] Univ Cambridge, Li Ka Shing Ctr, Canc Res UK Cambridge Inst, Cambridge CB2 0RE, England

[14] Johns Hopkins Univ, Sidney Kimmel Canc Ctr, Baltimore, MD 21287 USA

[15] Univ Lausanne Hosp, Lausanne, Switzerland

[16] Univ Penn, Penn Ovarian Canc Res Ctr, Philadelphia, PA 19104 USA

[17] Univ Manchester, Manchester M13 9WL, Lancs, England

[18] Univ Paris 06, Sorbonne Univ, UMRS1138,Lab Integrat Canc Immunol,INSERM, Cordeliers Res Ctr,Univ Paris Descartes,Sorbonne, F-75006 Paris, France

[19] Univ Edinburgh, Canc Res Ctr, Edinburgh EH4 2XR, Midlothian, Scotland

[20] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3052, Australia

[21] Univ British Columbia, Dept Pathol & Lab Med, Fac Med, Vancouver, BC V6T 2B5, Canada

[22] Univ British Columbia, Dept Obstet & Gynecol, Fac Med, Vancouver, BC V6T 2B5, Canada

[23] Harvard Univ, Sch Med, Boston, MA 02115 USA

[24] Ovarian Canc Act, London NW1 0JK, England

[25] Univ Chicago, Chicago, IL 60637 USA

[26] Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA

[27] Univ Glasgow, Glasgow G61 1QH, Lanark, Scotland

[28] UCL, Womens Canc, Inst Womens Hlth, London WC1E 6BT, England

[29] Womens Coll Res Inst, Toronto, ON M5G 1N8, Canada

[30] British Columbia Canc Agcy, Victoria, BC V8R 6V5, Canada

[31] Indiana Univ Sch Med, Bloomington, IN 47405 USA

[32] Simon Canc Ctr, Bloomington, IN 47405 USA

[33] Univ Cambridge, Strangeways Res Lab, Cambridge CB1 8RN, England

[34] Univ Penn, Philadelphia, PA 19104 USA

[35] Translat Genom Res Inst Tgen, Phoenix, AZ 85004 USA

来源：

NATURE REVIEWS CANCER | 2015年 / 15卷 / 11期

关键词：

OLAPARIB MAINTENANCE THERAPY; FALLOPIAN-TUBE; T-CELLS; BRCA2; MUTATIONS; GERMLINE MUTATIONS; SOMATIC MUTATIONS; MOUSE MODEL; POLY(ADP-RIBOSE) POLYMERASE; INTRAEPITHELIAL CARCINOMA; NEOADJUVANT CHEMOTHERAPY;

D O I：

10.1038/nrc4019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

High-grade serous ovarian cancer (HGSOC) accounts for 70-80% of ovarian cancer deaths, and overall survival has not changed significantly for several decades. In this Opinion article, we outline a set of research priorities that we believe will reduce incidence and improve outcomes for women with this disease. This 'roadmap' for HGSOC was determined after extensive discussions at an Ovarian Cancer Action meeting in January 2015.

引用

页码：668 / 679

页数：12

共 184 条

[1]

Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer [J].

Abkevich, V. ;

Timms, K. M. ;

Hennessy, B. T. ;

Potter, J. ;

Carey, M. S. ;

Meyer, L. A. ;

Smith-McCune, K. ;

Broaddus, R. ;

Lu, K. H. ;

Chen, J. ;

Tran, T. V. ;

Williams, D. ;

Iliev, D. ;

Jammulapati, S. ;

FitzGerald, L. M. ;

Krivak, T. ;

DeLoia, J. A. ;

Gutin, A. ;

Mills, G. B. ;

Lanchbury, J. S. .

BRITISH JOURNAL OF CANCER, 2012, 107 (10) :1776-1782

[2]

The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel [J].

Ahmed, Ahmed Ashour ;

Mills, Anthony D. ;

Ibrahim, Ashraf E. K. ;

Temple, Jillian ;

Blenkiron, Cherie ;

Vias, Maria ;

Massie, Charlie E. ;

Iyer, N. Gopalakrishna ;

McGeoch, Adam ;

Crawford, Robin ;

Nicke, Barbara ;

Downward, Julian ;

Swanton, Charles ;

Bell, Stephen D. ;

Earl, Helena M. ;

Laskey, Ronald A. ;

Caldas, Carlos ;

Brenton, James D. .

CANCER CELL, 2007, 12 (06) :514-527

[3]

Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary [J].

Ahmed, Ashour Ahmed ;

Etemadmoghadam, Dariush ;

Temple, Jillian ;

Lynch, Andy G. ;

Riad, Mohamed ;

Sharma, Raghwa ;

Stewart, Colin ;

Fereday, Sian ;

Caldas, Carlos ;

DeFazio, Anna ;

Bowtell, David ;

Brenton, James D. .

JOURNAL OF PATHOLOGY, 2010, 221 (01) :49-56

[4]

BRCA Mutation Frequency and Patterns of Treatment Response in BRCA Mutation-Positive Women With Ovarian Cancer: A Report From the Australian Ovarian Cancer Study Group [J].

Alsop, Kathryn ;

Fereday, Sian ;

Meldrum, Cliff ;

deFazio, Anna ;

Emmanuel, Catherine ;

George, Joshy ;

Dobrovic, Alexander ;

Birrer, Michael J. ;

Webb, Penelope M. ;

Stewart, Colin ;

Friedlander, Michael ;

Fox, Stephen ;

Bowtell, David ;

Mitchell, Gillian .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (21) :2654-2663

[5]

Multiplexed ion beam imaging of human breast tumors [J].

Angelo, Michael ;

Bendall, Sean C. ;

Finck, Rachel ;

Hale, Matthew B. ;

Hitzman, Chuck ;

Borowsky, Alexander D. ;

Levenson, Richard M. ;

Lowe, John B. ;

Liu, Scot D. ;

Zhao, Shuchun ;

Natkunam, Yasodha ;

Nolan, Garry P. .

NATURE MEDICINE, 2014, 20 (04) :436-+

[6]

Anglesio MS, 2013, PLOS ONE, V8, DOI [10.1371/journal.pone.0072162, 10.1371/annotation/ffcaf179-872f-470b-8bb6-f06d8ba6d03a]

[7]

Molecular subgroup of high-grade serous ovarian cancer (HGSOC) as a predictor of outcome following bevacizumab. [J].

Gourley, Charlie ;

McCavigan, Andrena ;

Perren, Timothy ;

Paul, James ;

Michie, Caroline Ogilvie ;

Churchman, Michael ;

Williams, Alistair ;

McCluggage, W. Glenn ;

Parmar, Mahesh ;

Kaplan, Richard S. ;

Hill, Laura A. ;

Haifpenny, Iris A. ;

O'Brien, Earnonn J. ;

Raji, Olaide ;

Deharo, Steve ;

Davison, Timothy ;

Johnston, Patrick ;

Keating, Katherine E. ;

Harkin, D. Paul ;

Kennedy, Richard D. .

JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)

[8]

[Anonymous], 2015, LANCET, DOI DOI 10.1016/S0140-6736(14)61687-1

[9]

[Anonymous], 2015, J NATL CANC I

[10]

[Anonymous], AM J OBSTET GYNECOL

← 1 2 3 4 5 6 7 8 9 10 →