The posttranscriptional regulator RsmA plays a role in the interaction between Pseudomonas aeruginosa and human airway epithelial cells by positively regulating the type III secretion system

被引：75

作者：

Mulcahy, H ^{[1
]}

O'Callaghan, J ^{[1
]}

O'Grady, EP ^{[1
]}

Adams, C ^{[1
]}

O'Gara, F ^{[1
]}

机构：

[1] Natl Univ Ireland Univ Coll Cork, BIOMERIT Res Ctr, Dept Microbiol, Cork, Ireland

来源：

INFECTION AND IMMUNITY | 2006年 / 74卷 / 05期

关键词：

D O I：

10.1128/IAI.74.5.3012-3015.2006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Posttranscriptional regulation of certain virulence-related genes in Pseudomonas aeruginosa is brought about by RsmA, a small RNA-binding protein. During interaction with airway epithelial cells, RsmA promoted actin depolymerization, cytotoxicity, and anti-internalization of P. aeruginosa by positively regulating the virulence-associated type III secretion system.

引用

页码：3012 / 3015

页数：4

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