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Total biosynthesis:: in vitro reconstitution of polyketide and nonribosomal peptide pathways

被引：150
作者：
Sattely, Elizabeth S. [1 ]
Fischbach, Michael A. [2 ]
Walsh, Christopher T. [1 ]
机构：
[1] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA
[2] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA
来源：
NATURAL PRODUCT REPORTS | 2008年 / 25卷 / 04期
关键词：
D O I：
10.1039/b801747f
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review Surveys efforts to reconstitute key steps in polyketide and nonribosomal peptide biosynthetic pathways with purified enzymes and substrates; 344 references are cited.
引用
收藏
页码：757 / 793
页数：37
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