The effect of orbitofrontal lesions on the error-related negativity

被引：37

作者：

Turken, U. ^{[1
]}

Swick, Diane ^{[1
,2
]}

机构：

[1] VANCHCS, Res Serv, Martinez, CA 94553 USA

[2] Univ Calif Davis, Dept Neurol, Davis, CA 95616 USA

来源：

NEUROSCIENCE LETTERS | 2008年 / 441卷 / 01期

基金：

美国国家科学基金会;

关键词：

ventromedial prefrontal cortex; error-related negativity; performance monitoring; error monitoring; anterior cingulate cortex;

D O I：

10.1016/j.neulet.2008.05.115

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Current theories of orbitofrontal cortex (OFC) function suggest that this region should participate in the generation of error-related signals associated with the outcomes of actions. We investigated the impact of lesions to OFC on the error-related negativity (ERN), an electrophysiological marker of performance monitoring. Four OFC patients and eight control subjects participated in a manual Stroop task while brain electrical activity was recorded. We found that the ERN was attenuated in the patient group. Three of the patients also had impaired error correction performance, but all showed normal post-error slowing. These findings suggest OFC involvement in monitoring and evaluation of ongoing performance. Published by Elsevier Ireland Ltd.

引用

页码：7 / 10

页数：4

共 31 条

[1] The role of emotion in decision-making: Evidence from neurological patients with orbitofrontal damage [J].