Pro-inflammatory prostaglandins and progression of colorectal cancer

被引：85

作者：

Wang, Dingzhi ^{[1
]}

DuBois, Raymond N. ^{[1
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN 37232 USA

来源：

CANCER LETTERS | 2008年 / 267卷 / 02期

基金：

美国国家卫生研究院;

关键词：

cyclooxygenase; prostaglandins; NSAIDs; inflammation; colorectal cancer; inflammatory bowel disease;

D O I：

10.1016/j.canlet.2008.03.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chronic inflammation is a risk factor for several gastrointestinal malignancies, including esophageal, gastric, hepatic, pancreatic and colorectal cancer. It has long been known that long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) reduces the relative risk of developing colorectal cancer. NSAIDs exert their anti-inflammatory and anti-tumor effects primarily by inhibiting activity of cyclooxygenase (COX) enzymes. Cyclooxygenase enzymes catalyze the conversion of arachidonic acid into prostanoids, including prostaglandins (PGs) and thromboxanes (TXs). Emerging evidence demonstrates that prostaglandins play an important role in inflammation and cancer. In this review, we highlight recent break-throughs in Our understanding of the roles of the different prostaglandins in colorectal cancer (CRC) and inflammatory bowel disease (IBD). These findings may provide it rationale for the development of new anti-inflammatory therapeutic approaches to cancer prevention and/or treatment. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：197 / 203

页数：7

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