High-dose cyclophosphamide in refractory myasthenia gravis with MuSK antibodies

被引：29

作者：

Lin, PT

Martin, BA

Weinacker, AB

So, YT ^{[1
]}

机构：

[1] Stanford Univ, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Med, Div Hematol, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Med, Div Pulm & Crit Care, Stanford, CA 94305 USA

来源：

MUSCLE & NERVE | 2006年 / 33卷 / 03期

关键词：

cyclophosphamide; mmune-system rebooting; muscle-specific tyrosine kinase; MuSK antibody; myasthenia gravis; seronegative;

D O I：

10.1002/mus.20411

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We describe a 48-year-old woman with seronegative myasthenia gravis (MG) and high-titer of anti-MuSK antibody. She had severe bulbar and respiratory weakness with minimal limb weakness for 2 years. Her disease responded poorly to all the conventional immunosuppressive regimens. Treatment with immunoablative dose of cyclophosphamide led to dramatic and sustained remission of her symptoms. High-dose cyclophosphamide is an effective alternative in patients with unusually refractory disease.

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页码：433 / 435

页数：3

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