Primary chronic autoimmune neutropenia successfully treated with sirolimus

被引：9

作者：

Ghnaya, H. ^{[1
]}

Bekov, K. ^{[1
]}

Jira, M. ^{[1
]}

Kettaneh, A. ^{[1
]}

Mejri, O. ^{[1
]}

Tiev, K. P. ^{[1
]}

Gain, M. ^{[1
]}

Cabane, J. ^{[1
]}

机构：

[1] Univ Paris 06, Hop St Antoine, AP HP, Serv Med Interne, F-75012 Paris, France

来源：

REVUE DE MEDECINE INTERNE | 2008年 / 29卷 / 11期

关键词：

Chronic autoimmune neutropenia; Sirolimus;

D O I：

10.1016/j.revmed.2008.02.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a 74-year-old mean with severe chronic primary neurtropenia (neutrophil count: 390 per millimeter cube) uncovered following surgery for perianal abscess collection. Clinical, laboratory and roentgenographic findings revealed no abnormality. Antineutrophil antibodies were positive in two consecutive serum samples. Under cyclosporine, neutrophil count reached 1970 per millimeter cube. However, this therapy was discontinued due to new onset of severe renal failure. After six weeks, neutrophil count was 950 per millimeter cube and sirolimus was started, resulting in renal (C) ELsevier Masson SAS. Tous droits reserves.

引用

页码：940 / 942

页数：3

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