An efficient method for the N-debenzylation of aromatic heterocycles

被引：100

作者：

Haddach, AA

Kelleman, A

Deaton-Rewolinski, MV

机构：

[1] Pfizer Co, Agouron Pharmaceut Inc, San Diego, CA 92121 USA

[2] Univ Calif San Diego, Dept Chem, San Diego, CA 92103 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 03期

关键词：

D O I：

10.1016/S0040-4039(01)02192-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The treatment of N-benzylated heterocycles with potassium tert-butoxide/DMSO and oxygen at room temperature cleanly affords N-debenzylated products in high yield. This procedure can be utilized on a variety of functionalized nitrogen-containing heterocycles such as imidazoles, benzimidazoles, pyrazoles, indazoles, carbazoles, and indoles. (C) 2002 Published by Elsevier Science Ltd.

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页码：399 / 402

页数：4

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