Stereoselective synthesis of syn-2,7-disubstituted-4,5-oxepenes

被引：22

作者：

Díaz, DD ^{[1
]}

Betancort, JM ^{[1
]}

Crisóstomo, FRP ^{[1
]}

Martín, T ^{[1
]}

Martín, VS ^{[1
]}

机构：

[1] Univ La Laguna, Inst Univ Bioorgan Antonio Gonzalez, San Cristobal la Laguna 38206, Tenerife, Spain

来源：

TETRAHEDRON | 2002年 / 58卷 / 10期

关键词：

marine metabolites; oxepenes; Nicholas reaction;

D O I：

10.1016/S0040-4020(02)00046-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of the title compounds as pure enantiomers is reported. The method is based on the intramolecular trapping group of a carbocation generated by acid treatment of exo-Co-2(CO)(6)-propargyl alcohols by a stereochemically controlled secondary hydroxy a up located in a suitable chain. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1913 / 1919

页数：7

共 46 条

[1] USEFUL DESIGNS IN THE SYNTHESIS OF TRANS-FUSED POLYETHER TOXINS [J].