Activation of the lamin A gene during rat liver development

被引：15

作者：

Hamid, QA ^{[1
]}

Fatima, S ^{[1
]}

Thanumalayan, S ^{[1
]}

Parnaik, VK ^{[1
]}

机构：

[1] CTR CELLULAR & MOL BIOL, HYDERABAD 500007, ANDHRA PRADESH, INDIA

来源：

FEBS LETTERS | 1996年 / 392卷 / 02期

关键词：

lamin A gene; nuclear lamina; liver development;

D O I：

10.1016/0014-5793(96)00802-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have studied the regulation of expression of the A-type lamins, which are constituents of the nuclear lamina, During rat liver development, high levels of lamin A and C mRNAs were observed in 15-day fetal liver but were barely detectable in the adult, The chromatin conformation of the lamin A gene was sensitive to DNase I in 15-day fetal liver but became mostly insensitive in the adult, Lamin A and C proteins could be detected in fetal liver and persisted in the adult, Our evidence suggests that the lamin A gene is actively transcribed early in liver differentiation and its activity declines considerably in adult liver.

引用

页码：137 / 142

页数：6

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