How does Pol II overcome the nucleosome barrier?

被引：13

作者：

Adelman, K ^{[1
]}

Lis, JT

机构：

[1] Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA

[2] Cornell Univ, Dept Phys, Ithaca, NY 14853 USA

来源：

MOLECULAR CELL | 2002年 / 9卷 / 03期

关键词：

D O I：

10.1016/S1097-2765(02)00487-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA packaging into chromatin presents a strong barrier to RNA polymerase 11 transcription. In this issue of Molecular Cell, Kireeva et al. describe a minimal system to examine polymerase 11 transcription through a positioned nucleosome and show, surprisingly, that transcription leads to the displacement of an H2A-H2B dimer from the nucleosome without altering nucleosome position.

引用

页码：451 / 452

页数：2

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