Targeting the p53 Pathway

被引：30

作者：

Golubovskaya, Vita M. ^{[1
,2
]}

Cance, William G. ^{[1
,2
,3
]}

机构：

[1] Roswell Pk Canc Inst, Dept Surg Oncol, Buffalo, NY 14127 USA

[2] CureFAKtor Pharmaceut, Buffalo, NY USA

[3] SUNY Buffalo, Dept Surg, Buffalo, NY 14260 USA

来源：

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA | 2013年 / 22卷 / 04期

关键词：

p53; Mdm-2; FAK; Survival; Apoptosis; FOCAL-ADHESION KINASE; SMALL-MOLECULE INHIBITOR; MDM-2 ANTAGONIST NUTLIN-3; SQUAMOUS-CELL CARCINOMA; AMINO-TERMINAL DOMAIN; PROLINE-RICH REGION; MUTANT P53; BREAST-CANCER; BINDING-SITE; TUMOR-GROWTH;

D O I：

10.1016/j.soc.2013.06.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This article summarizes data on translational studies to target the p53 pathway in cancer. It describes the functions of the p53 and Mdm-2 signaling pathways, and discusses current therapeutic approaches to target p53 pathways, including reactivation of p53. In addition, direct interaction and colocalization of the p53 and focal adhesion kinase proteins in cancer cells have been demonstrated, and different approaches to target this interaction are reviewed. This is a broad review of p53 function as it relates to the diagnosis and treatment of a wide range of cancers.

引用

页码：747 / +

页数：19

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