Epigenetic reprogramming and induced pluripotency

被引：398

作者：

Hochedlinger, Konrad ^{[1
,2
]}

Plath, Kathrin ^{[3
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA

[2] Harvard Univ, Ctr Regenerat Med, Dept Stem Cell & Regenerat Biol, Harvard Stem Cell Inst, Boston, MA 02114 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Biol Chem,Eli & Edythe Broad Ctr Regenerat M, Jonsson Comprehens Canc Ctr,Mol Biol Inst, Los Angeles, CA 90024 USA

来源：

DEVELOPMENT | 2009年 / 136卷 / 04期

关键词：

EMBRYONIC STEM-CELLS; PRIMORDIAL GERM-CELLS; PANCREATIC BETA-CELLS; HUMAN SOMATIC-CELLS; DNA METHYLATION; NUCLEAR TRANSFER; DEVELOPMENTAL POTENTIALITIES; TRANSCRIPTIONAL REPRESSION; HUMAN FIBROBLASTS; SELF-RENEWAL;

D O I：

10.1242/dev.020867

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The cloning of animals from adult cells has demonstrated that the developmental state of adult cells can be reprogrammed into that of embryonic cells by uncharacterized factors within the oocyte. More recently, transcription factors have been identified that can induce pluripotency in somatic cells without the use of oocytes, generating induced pluripotent stem (iPS) cells. iPS cells provide a unique platform to dissect the molecular mechanisms that underlie epigenetic reprogramming. Moreover, iPS cells can teach us about principles of normal development and disease, and might ultimately facilitate the treatment of patients by custom-tailored cell therapy.

引用

页码：509 / 523

页数：15

共 168 条

[1] Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes [J].