Global standardization measurement of cerebral spinal fluid for Alzheimer's disease: An update from the Alzheimer's Association Global Biomarkers Consortium

被引：92

作者：

Carrillo, Maria C. ^{[1
]}

Blennow, Kaj ^{[2
]}

Soares, Holly ^{[3
]}

Lewczuk, Piotr ^{[4
,5
]}

Mattsson, Niklas ^{[2
]}

Oberoi, Pankaj ^{[6
]}

Umek, Robert ^{[6
]}

Vandijck, Manu ^{[7
]}

Salamone, Salvatore ^{[8
]}

Bittner, Tobias ^{[9
]}

Shaw, Leslie M. ^{[10
,11
]}

Stephenson, Diane ^{[12
]}

Bain, Lisa

Zetterberg, Henrik ^{[2
,13
]}

机构：

[1] Alzheimers Assoc, Div Med & Sci Relat, Chicago, IL 60601 USA

[2] Univ Goteborg, Inst Neurosc & Physiol, Dept Psychiat & Neurochem, Clin Neurochem Lab, Molndal, Sweden

[3] Bristol Myers Squibb, Groton, CT USA

[4] Univ Klinikum Erlangen, Dept Psychiat & Psychotherapy, Erlangen, Germany

[5] Univ Erlangen Nurnberg, D-91054 Erlangen, Germany

[6] Meso Scale Discovery, Gaithersburg, MD USA

[7] Innogenetics, Ghent, Belgium

[8] Saladax Biomed, Bethlehem, PA USA

[9] Roche Diagnost, Indianapolis, IN USA

[10] Univ Penn, Dept Pathol, Perelman Sch Med, Philadelphia, PA 19104 USA

[11] Univ Penn, Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA

[12] Crit Path Inst, Tucson, AZ USA

[13] UCL Inst Neurol, London, England

来源：

ALZHEIMERS & DEMENTIA | 2013年 / 9卷 / 02期

关键词：

Alzheimer's disease; Biomarkers; Cerebral spinal fluid; Early diagnosis; Standardization; Assay development; Precompetetive; DEMENTIA;

D O I：

10.1016/j.jalz.2012.11.003

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Recognizing that international collaboration is critical for the acceleration of biomarker standardization efforts and the efficient development of improved diagnosis and therapy, the Alzheimer's Association created the Global Biomarkers Standardization Consortium (GBSC) in 2010. The consortium brings together representatives of academic centers, industry, and the regulatory community with the common goal of developing internationally accepted common reference standards and reference methods for the assessment of cerebrospinal fluid (CSF) amyloid beta 42 (A beta 42) and tau biomarkers. Such standards are essential to ensure that analytical measurements are reproducible and consistent across multiple laboratories and across multiple kit manufacturers. Analytical harmonization for CSF A beta 42 and tau will help reduce confusion in the AD community regarding the absolute values associated with the clinical interpretation of CSF biomarker results and enable worldwide comparison of CSF biomarker results across AD clinical studies. (c) 2013 The Alzheimer's Association. All rights reserved.

引用

页码：137 / 140

页数：4

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