Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans

被引：166

作者：

Sanapareddy, Nina ^{[2
]}

Legge, Ryan M. ^{[3
]}

Jovov, Biljana ^{[1
]}

McCoy, Amber ^{[1
]}

Burcal, Lauren ^{[1
]}

Araujo-Perez, Felix ^{[1
]}

Randall, Thomas A. ^{[4
]}

Galanko, Joseph ^{[1
]}

Benson, Andrew ^{[3
]}

Sandler, Robert S. ^{[1
]}

Rawls, John F. ^{[5
]}

Abdo, Zaid ^{[6
]}

Fodor, Anthony A. ^{[2
]}

Keku, Temitope O. ^{[1
]}

机构：

[1] Univ N Carolina Chapel Hill, Ctr Gastrointestinal Biol & Dis, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Bioinformat & Genom, Charlotte, NC 28223 USA

[3] Univ Nebraska, Dept Food Sci & Technol, Lincoln, NE 68583 USA

[4] Univ N Carolina Chapel Hill, Ctr Bioinformat, Chapel Hill, NC 27599 USA

[5] Univ N Carolina Chapel Hill, Dept Cell & Mol Physiol, Chapel Hill, NC 27599 USA

[6] Univ Idaho, Dept Math & Stat, Moscow, ID 83843 USA

来源：

ISME JOURNAL | 2012年 / 6卷 / 10期

基金：

美国国家卫生研究院;

关键词：

BMI; colon cancer; diagnostic; commensal bacteria; HELICOBACTER-PYLORI INFECTION; CORE GUT MICROBIOME; CANCER; OBESITY; EXPRESSION; DIVERSITY; BACTERIA; ECOLOGY; GENERATION; RESISTANCE;

D O I：

10.1038/ismej.2012.43

中图分类号：

Q14 [生态学（生物生态学）];

学科分类号：

071012 ; 0713 ;

摘要：

Differences in the composition of the gut microbial community have been associated with diseases such as obesity, Crohn's disease, ulcerative colitis and colorectal cancer (CRC). We used 454 titanium pyrosequencing of the V1-V2 region of the 16S rRNA gene to characterize adherent bacterial communities in mucosal biopsy samples from 33 subjects with adenomas and 38 subjects without adenomas (controls). Biopsy samples from subjects with adenomas had greater numbers of bacteria from 87 taxa than controls; only 5 taxa were more abundant in control samples. The magnitude of the differences in the distal gut microbiota between patients with adenomas and controls was more pronounced than that of any other clinical parameters including obesity, diet or family history of CRC. This suggests that sequence analysis of the microbiota could be used to identify patients at risk for developing adenomas. The ISME Journal (2012) 6, 1858-1868; doi:10.1038/ismej.2012.43; published online 24 May 2012

引用

页码：1858 / 1868

页数：11

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