Roles of metabotropic glutamate receptors in LTP and LTD in the hippocampus

被引：160

作者：

Bortolotto, ZA ^{[1
]}

Fitzjohn, SM ^{[1
]}

Collingridge, GL ^{[1
]}

机构：

[1] Univ Bristol, Sch Med Sci, Dept Anat, MRC,Ctr Synapt Plast, Bristol BS8 1TD, Avon, England

来源：

CURRENT OPINION IN NEUROBIOLOGY | 1999年 / 9卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0959-4388(99)80044-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Metabotropic L-glutamate receptors are involved in various forms of synaptic plasticity in the hippocampus. The use of a new antagonist (LY341495) that blocks all known metabotropic L-glutamate receptors in the brain, together with subtype-selective antagonists, has identified multiple roles both for cloned and novel metabotropic L-glutamate receptors in hippocampal long-term potentiation and long-term depression.

引用

页码：299 / 304

页数：6

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