The copper mediated barbier reactions of α,β-unsaturated ketones:: Regioselective conjugate and 1,2-addition

被引：2

作者：

Costello, DP ^{[1
]}

Geraghty, NWA ^{[1
]}

机构：

[1] Natl Univ Ireland Univ Coll Galway, Dept Chem, Galway, Ireland

来源：

SYNTHETIC COMMUNICATIONS | 1999年 / 29卷 / 18期

关键词：

D O I：

10.1080/00397919908085932

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The one-pot reaction of isophorone and other alpha,beta-unsaturated ketones with alkyl and aryl halides in the presence of magnesium and a copper salt ("Barbier" conditions) leads to the regiospecific formation of 1,4-addition products; the use of lithium leads to regioselective 1,2-addition.

引用

页码：3083 / 3096

页数：14

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