Secretion and clearance of the mature form of adrenomedullin in humans

被引:44
作者
Hirayama, N [1 ]
Kitamura, K [1 ]
Imamura, T [1 ]
Kato, J [1 ]
Koiwaya, Y [1 ]
Eto, T [1 ]
机构
[1] Miyazaki Med Coll, Dept Internal Med 1, Kiyotake, Miyazaki 8891692, Japan
关键词
adrenomedullin; molecular forms; mature form; intermediate form; adrenomedullin secretion; adrenomedullin clearance;
D O I
10.1016/S0024-3205(99)00208-8
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
In the biosynthesis of adrenomedullin (AM), glycine-extended ANP, an intermediate form (iAM) processed from proAM is converted to AM[1-52]-NH2, the bioactive mature form of AM (mAM), by enzymatic amidation. We earlier showed that both molecular forms of AM circulate in human plasma. In the present study, to investigate the secretion and clearance sites of mAM and iAM in humans, we examined the plasma mAM and iAM concentrations in the femoral artery and vein (FA and FV), the aortic root and coronary sinus (AO and CS), and the pulmonary artery and capillary (PA and PC) of patients with ischemic heart disease. Plasma mAM in FV was significantly (p<0.001) higher than in FA There also was a significant (p<0.001) step-up in the plasma mAM of the CS as compared to the AO. In contrast, plasma mAM was significantly (p<0.001) reduced in the PC as compared to the PA. However, such differences were not observed in plasma iAM levels. These findings suggest that in humans the vasculature of the lower extremities and the heart produce and secrete mAM and that the lung is a clearance site of circulating mAM.
引用
收藏
页码:2505 / 2509
页数:5
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