Atractylodis macrocephalae Koidz. polysaccharides enhance both serum IgG response and gut mucosal immunity

被引：107

作者：

Xie, Feng ^{[1
,2
]}

Sakwiwatkul, Kedsirin ^{[3
]}

Zhang, Cenrong ^{[1
]}

Wang, Yueming ^{[1
]}

Zhai, Lijuan ^{[1
]}

Hu, Songhua ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Anim Sci, Dept Vet Med, Hangzhou 310058, Zhejiang, Peoples R China

[2] Zhejiang Acad Med Sci, Natl Ctr Safety Evaluat New Drugs, Hangzhou 310013, Zhejiang, Peoples R China

[3] Mahasarakham Univ, Fac Vet & Anim Sci, Dept Anim Sci, Muang 44000, Mahasarakham, Thailand

来源：

CARBOHYDRATE POLYMERS | 2013年 / 91卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Mucosal immunity; Atractylodis macrocephalae Koidz; Polysaccharide; Adjuvant; LEAF SAPONINS GSLS; INTRAEPITHELIAL LYMPHOCYTES; MOUTH-DISEASE; CELLS; ADJUVANT; INTERLEUKIN-6; VACCINATION; EXPRESSION; ANTIGENS; RECEPTOR;

D O I：

10.1016/j.carbpol.2012.07.083

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

Fifty-six mice were randomly divided into four groups with 14 mice in each. Two groups were subcutaneously injected twice with a foot-and-mouth disease vaccine with 2-week intervals: each of them had been orally administered 0.89% saline or Atractylodis macrocephalae Koidz. polysaccharides (RAMPS) 0.05 g for 4 days before immunization. The rest were not immunized but treated in the same way. One-week after the primary and two weeks after the booster immunization, half in each group were sacrificed to measure serum IgG and the parameters for the intestinal mucosal immunity. Results indicated that oral administration of RAMPS increased both serum specific IgG response and intestinal mucosal immunity as shown by elevated total sIgA, mRNA expression of TGF-beta, IL-6, TNF-alpha, IgA(+) cells and intestinal intraepithelial lymphocytes in duodenum. It is suggested that increased serum IgG response may be associated with enhanced local mucosal immunity by oral administration of RAMPS. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：68 / 73

页数：6

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