Construction of molecular logic gates with a DNA-cleaving deoxyribozyme

被引：71

作者：

Chen, X

Wang, YF

Liu, Q

Zhang, ZZ ^{[1
]}

Fan, CH

He, L

机构：

[1] Shanghai Jiao Tong Univ, BioX Life Sci Res Ctr, Shanghai 200030, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China

[3] Tianjin Univ Sci & Technol, Tianjin 300040, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 11期

关键词：

biosensors; DNA; molecular devices; ribozymes;

D O I：

10.1002/anie.200502511

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A logical conclusion: DNA logic gates constructed by using a Cu 2+-dependent DNA-cleaving deoxyribozyme are as efficient as the relatively unstable ribonucleotide-containing systems. The inputs (effectors), gates (deoxyribozymes), and outputs (substrates) are represented by chemically robust DNA oligonucleotides, which perform logic operations including "YES", "NOT", and "AND(A,NOT(B),NOT(C))" (see picture). (Chemical Equation Presented) © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：1759 / 1762

页数：4

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