Review: Molecular mechanism of microglia stimulated glioblastoma invasion

被引：104

作者：

Coniglio, Salvatore J. ^{[1
]}

Segall, Jeffrey E. ^{[1
,2
]}

机构：

[1] Albert Einstein Coll Med, Dept Anat & Struct Biol, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Gruss Lipper Biophoton Ctr, Bronx, NY 10461 USA

来源：

MATRIX BIOLOGY | 2013年 / 32卷 / 7-8期

关键词：

Glioma; Microglia; Macrophages; Invasion; CSF-1R; MMPs; TGF beta; GROWTH-FACTOR-RECEPTOR; GLIOMA-CELL INVASION; HUMAN-BRAIN TUMORS; CANCER STEM-CELLS; MATRIX METALLOPROTEINASES; TGF-BETA; IN-VITRO; MACROPHAGE INFILTRATION; SUPPRESSOR-CELLS; ALPHA-5-BETA-1; INTEGRIN;

D O I：

10.1016/j.matbio.2013.07.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Glioblastoma multiforme is one of the deadliest human cancers and is characterized by a high degree of microglia and macrophage infiltration. The role of these glioma infiltrating macrophages (GIMs) in disease progression has been the subject of recent investigation. While initially thought to reflect an immune response to the tumor, the balance of evidence clearly suggests GIMs can have potent tumor-tropic functions and assist in glioma cell growth and infiltration into normal brain. In this review, we focus on the evidence for GIMs aiding mediating glioblastoma motility and invasion. We survey the literature for molecular pathways that are involved in paracrine interaction between glioma cells and GIMs and assess which of these might serve as attractive targets for therapeutic intervention. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：372 / 380

页数：9

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