To spread or not to spread - chromatin modifications in response to DNA damage

被引：40

作者：

Altmeyer, Matthias ^{[1
]}

Lukas, Jiri ^{[1
]}

机构：

[1] Univ Copenhagen, Chromosome Stabil & Dynam Unit, Dept Dis Biol, Novo Nordisk Fdn Ctr Prot Res, DK-2200 Copenhagen, Denmark

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2013年 / 23卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

STRAND BREAK REPAIR; UBIQUITIN E3 LIGASE; HOMOLOGOUS RECOMBINATION; CHROMOSOMAL TRANSLOCATIONS; 53BP1; RECRUITMENT; SEX-CHROMOSOMES; HISTONE H2AX; PROMOTES; GENOME; MDC1;

D O I：

10.1016/j.gde.2012.11.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Chromatin modifications in response to DNA damage are vital for genome integrity. Multiple proteins and pathways required to generate specialized chromatin domains around DNA lesions have been identified and the increasing amount of information calls for unifying concepts that would allow us to grasp the ever-increasing complexity. This review aims at contributing to this trend by focusing on feed-forward-and feedback mechanisms, which in mammalian cells determine the extent of chromatin modifications after DNA damage. We highlight the emerging notion that the nodal points of these highly dynamic pathways operate in a rate-limiting mode, whose deregulation can disrupt physiological boundaries between damaged and undamaged chromatin, dictate repair pathway choice, and determine the fate of cells exposed to genotoxic stress.

引用

收藏

页码：156 / 165

页数：10

相关论文

共 95 条

[1] The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks [J].

Acs, Klara ;

Luijsterburg, Martijn S. ;

Ackermann, Leena ;

Salomons, Florian A. ;

Hoppe, Thorsten ;

Dantuma, Nico P. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2011, 18 (12) :1345-U55

[2] Poly(ADP-ribose)-Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1 [J].

Ahel, Dragana ;

Horejsi, Zuzana ;

Wiechens, Nicola ;

Polo, Sophie E. ;

Garcia-Wilson, Elisa ;

Ahel, Ivan ;

Flynn, Helen ;

Skehel, Mark ;

West, Stephen C. ;

Jackson, Stephen P. ;

Owen-Hughes, Tom ;

Boulton, Simon J. .

SCIENCE, 2009, 325 (5945) :1240-1243

[3] The ubiquitous role of ubiquitin in the DNA damage response [J].

Al-Hakim, Abdallah ;

Escribano-Diaz, Cristina ;

Landry, Marie-Claude ;

O'Donnell, Lara ;

Panier, Stephanie ;

Szilard, Rachel K. ;

Durocher, Daniel .

DNA REPAIR, 2010, 9 (12) :1229-1240

[4] The role of deubiquitinating enzymes in chromatin regulation [J].

Atanassov, Boyko S. ;

Koutelou, Evangelia ;

Dent, Sharon Y. .

FEBS LETTERS, 2011, 585 (13) :2016-2023

[5] The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks [J].

Bekker-Jensen, Simon ;

Mailand, Niels .

FEBS LETTERS, 2011, 585 (18) :2914-2919

[6] Assembly and function of DNA double-strand break repair foci in mammalian cells [J].

Bekker-Jensen, Simon ;

Mailand, Niels .

DNA REPAIR, 2010, 9 (12) :1219-1228

[7] ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2 [J].

Beucher, Andrea ;

Birraux, Julie ;

Tchouandong, Leopoldine ;

Barton, Olivia ;

Shibata, Atsushi ;

Conrad, Sandro ;

Goodarzi, Aaron A. ;

Krempler, Andrea ;

Jeggo, Penny A. ;

Loebrich, Markus .

EMBO JOURNAL, 2009, 28 (21) :3413-3427

[8] Regulation of DNA End Joining, Resection, and Immunoglobulin Class Switch Recombination by 53BP1 [J].

Bothmer, Anne ;

Robbiani, Davide F. ;

Di Virgilio, Michela ;

Bunting, Samuel F. ;

Klein, Isaac A. ;

Feldhahn, Niklas ;

Barlow, Jacqueline ;

Chen, Hua-Tang ;

Bosque, David ;

Callen, Elsa ;

Nussenzweig, Andre ;

Nussenzweig, Michel C. .

MOLECULAR CELL, 2011, 42 (03) :319-329

[9] 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination [J].

Bothmer, Anne ;

Robbiani, Davide F. ;

Feldhahn, Niklas ;

Gazumyan, Anna ;

Nussenzweig, Andre ;

Nussenzweig, Michel C. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2010, 207 (04) :855-865

[10] 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers [J].

Bouwman, Peter ;

Aly, Amal ;

Escandell, Jose M. ;

Pieterse, Mark ;

Bartkova, Jirina ;

van der Gulden, Hanneke ;

Hiddingh, Sanne ;

Thanasoula, Maria ;

Kulkarni, Atul ;

Yang, Qifeng ;

Haffty, Bruce G. ;

Tommiska, Johanna ;

Blomqvist, Carl ;

Drapkin, Ronny ;

Adams, David J. ;

Nevanlinna, Heli ;

Bartek, Jiri ;

Tarsounas, Madalena ;

Ganesan, Shridar ;

Jonkers, Jos .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2010, 17 (06) :688-U56

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