Lactobacillus fermentum RC-14 inhibits Staphylococcus aureus infection of surgical implants in rats

被引：105

作者：

Gan, BS

Kim, J

Reid, G

Cadieux, P

Howard, JC

机构：

[1] Univ Western Ontario, Lawson Hlth Res Inst, London, ON N6A 4V2, Canada

[2] Univ Western Ontario, Hand & Upper Limb Ctr, London, ON N6A 4V2, Canada

[3] Univ Western Ontario, Dept Surg, London, ON N6A 4V2, Canada

[4] Univ Western Ontario, Dept Pharmacol & Toxicol, London, ON N6A 4V2, Canada

[5] Univ Western Ontario, Dept Med Biophys, London, ON N6A 4V2, Canada

[6] Univ Western Ontario, Dept Microbiol & Immunol, London, ON N6A 4V2, Canada

[7] Univ Western Ontario, Dept Biochem, London, ON N6A 4V2, Canada

来源：

JOURNAL OF INFECTIOUS DISEASES | 2002年 / 185卷 / 09期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1086/340126

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Staphylococcus aureus is a common cause of community and hospital-acquired infections. Moreover, the clinical impact of S. aureus is on the rise because of the global increase in the incidence of multidrug-resistant strains and its growing prevalence as a major cause of surgical infections. As a result, there is a pressing need to identify new antistaphylococcal agents and preventative strategies that will help in the management of these types of infections. This report describes the successful use of a probiotic, Lactobacillus fermentum RC-14, and its secreted biosurfactant to inhibit surgical implant infections caused by S. aureus. L. fermentum RC-14 and its secreted biosurfactant both significantly inhibited S. aureus infection and bacteria adherence to surgical implants.

引用

页码：1369 / 1372

页数：4

共 14 条

[1] A SIMPLE METHOD FOR THE ISOLATION OF CHROMOSOMAL DNA FROM GRAM-POSITIVE OR ACID-FAST BACTERIA [J].