Accurate measurement and clinical significance of urinary transforming growth factor-beta

被引：41

作者：

Tsakas, Sotiris ^{[1
]}

Goumenos, Dimitrios S.

机构：

[1] Univ Patras, Biol Lab, Dept Biol, GR-26500 Patras, Greece

[2] Univ Hosp Patras, Patras, Greece

来源：

AMERICAN JOURNAL OF NEPHROLOGY | 2006年 / 26卷 / 02期

关键词：

transforming growth factor-beta(1); enzyme immunoassay; proteinuria; glomerular injury;

D O I：

10.1159/000093178

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Transforming growth factor beta(1), (TGF-beta(1)) is the main modulator of the healing process after tissue injury. In the kidney, if TGF-beta(1) release is not switched off, extracellular matrix components (ECM) are accumulated and tissue fibrosis occurs. Urinary TGF-beta(1) levels reflect its renal production and it has been determined in various types of glomerular disease. In this review, a critical analysis of the different immunoassays that have been used for the measurement of TGF-beta(1) in the urine is presented and the importance of the serial determination of urinary TGF-beta(1) levels in patients with various types of renal disease is discussed. Copyright (c) 2006 S. Karger AG, Basel.

引用

页码：186 / 193

页数：8

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