Potential biomarker of coal workers' pneumoconiosis

被引：17

作者：

Kim, KA ^{[1
]}

Lim, Y ^{[1
]}

Kim, JH ^{[1
]}

Kim, EK ^{[1
]}

Chang, HS ^{[1
]}

Park, YM ^{[1
]}

Ahn, BY ^{[1
]}

机构：

[1] Catholic Univ Korea, Coll Med, St Marys Hosp, Dept Ind Med, Seoul 150010, South Korea

来源：

TOXICOLOGY LETTERS | 1999年 / 108卷 / 2-3期

关键词：

pneumoconiosis; cytokines; growth factors; TNF-alpha; IL-8;

D O I：

10.1016/S0378-4274(99)00101-0

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

It is well known that various cytokines and growth factors secreted from macrophages/monocytes play the key role in the pathogenesis of pneumoconiosis. These can act as biosensors for the prediction of pneumoconiosis. To evaluate which cytokines can be used as sensitive biomarkers in pneumoconiosis, we measured tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8) and platelet-derived growth factor-AA (PDGF-AA) in supernatant of monocytes with or without coal dust (5 mg/ml) and serum in 42 coal miners with pneumoconiosis and ten healthy control. The coal-stimulated release of TNF-alpha and IL-8 from blood monocytes was significant increased in pneumoconiosis patients compared with controls, The level of TNF-alpha and IL-8 in blood serum was higher in subjects with pneumoconiosis than in controls. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：297 / 302

页数：6

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