Effects of structural modification on gene transfection and self-assembling properties of amphiphilic dendrimers

被引:52
作者
Guillot, M
Eisler, S
Weller, K
Merkle, HP
Gallani, JL
Diederich, F [1 ]
机构
[1] ETH, Organ Chem Lab, CH-8093 Zurich, Switzerland
[2] ETH, Inst Pharmazeut Wissenschaften, CH-8093 Zurich, Switzerland
[3] Inst Phys & Chim Mat Strasbourg, F-67034 Strasbourg, France
关键词
D O I
10.1039/b518174g
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A library of novel amphiphilic, self-assembling dendrimers was designed and synthesised to evaluate the effects of structural changes on transfection efficiency.
引用
收藏
页码:766 / 769
页数:4
相关论文
共 37 条
[1]   New multivalent cationic lipids reveal bell curve for transfection efficiency versus membrane charge density: lipid-DNA complexes for gene delivery [J].
Ahmad, A ;
Evans, HM ;
Ewert, K ;
George, CX ;
Samuel, CE ;
Safinya, CR .
JOURNAL OF GENE MEDICINE, 2005, 7 (06) :739-748
[2]  
[Anonymous], INTERMOLECULAR SURFA
[3]  
Behr JP, 1997, CHIMIA, V51, P34
[4]   Transfection mediated by gemini surfactants: Engineered escape from the endosomal compartment [J].
Bell, PC ;
Bergsma, M ;
Dolbnya, IP ;
Bras, W ;
Stuart, MCA ;
Rowan, AE ;
Feiters, MC ;
Engberts, JBFN .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (06) :1551-1558
[5]  
Bharali DJ, 2005, P NATL ACAD SCI USA, V102, P11539, DOI 10.1073/pnas.0504926102
[6]   DNA complexing with polyamidoamine dendrimers: Implications for transfection [J].
Bielinska, AU ;
Chen, CL ;
Johnson, J ;
Baker, JR .
BIOCONJUGATE CHEMISTRY, 1999, 10 (05) :843-850
[7]   Dendrimers in drug research [J].
Boas, U ;
Heegaard, PMH .
CHEMICAL SOCIETY REVIEWS, 2004, 33 (01) :43-63
[8]   Synthesis, activity, and structure-activity relationship studies of novel cationic lipids for DNA transfer [J].
Byk, G ;
Dubertret, C ;
Escriou, V ;
Frederic, M ;
Jaslin, G ;
Rangara, R ;
Pitard, B ;
Crouzet, J ;
Wils, P ;
Schwartz, B ;
Scherman, D .
JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (02) :224-235
[9]   Effect of chain length on transfection properties of spermine-based gemini surfactants [J].
Castro, M ;
Griffiths, D ;
Patel, A ;
Pattrick, N ;
Kitson, C ;
Ladlow, M .
ORGANIC & BIOMOLECULAR CHEMISTRY, 2004, 2 (19) :2814-2820
[10]   THE ROLE OF DIOLEOYL PHOSPHATIDYLETHANOLAMINE IN CATIONIC LIPOSOME-MEDIATED GENE-TRANSFER [J].
FARHOOD, H ;
SERBINA, N ;
HUANG, L .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1995, 1235 (02) :289-295