Effects of structural modification on gene transfection and self-assembling properties of amphiphilic dendrimers

被引:52
作者
Guillot, M
Eisler, S
Weller, K
Merkle, HP
Gallani, JL
Diederich, F [1 ]
机构
[1] ETH, Organ Chem Lab, CH-8093 Zurich, Switzerland
[2] ETH, Inst Pharmazeut Wissenschaften, CH-8093 Zurich, Switzerland
[3] Inst Phys & Chim Mat Strasbourg, F-67034 Strasbourg, France
关键词
D O I
10.1039/b518174g
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A library of novel amphiphilic, self-assembling dendrimers was designed and synthesised to evaluate the effects of structural changes on transfection efficiency.
引用
收藏
页码:766 / 769
页数:4
相关论文
共 37 条
[31]   Kanamycin A-derived cationic lipids as vectors for gene transfection [J].
Sainlos, M ;
Hauchecorne, M ;
Oudrhiri, N ;
Zertal-Zidani, S ;
Aissaoui, A ;
Vigneron, JP ;
Lehn, JM ;
Lehn, P .
CHEMBIOCHEM, 2005, 6 (06) :1023-1033
[32]   Sunfish cationic amphiphiles:: Toward an adaptative lipoplex morphology [J].
Scarzello, M ;
Smisterová, J ;
Wagenaar, A ;
Stuart, MCA ;
Hoekstra, D ;
Engberts, JBFN ;
Hulst, R .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (29) :10420-10429
[33]   Materials for non-viral gene delivery [J].
Segura, T ;
Shea, LD .
ANNUAL REVIEW OF MATERIALS RESEARCH, 2001, 31 :25-46
[34]   STRUCTURAL EFFECT ON THE ADSORPTION PROPERTIES OF AQUEOUS-SOLUTIONS OF STRAIGHT-CHAIN AND CYCLIC DODECYL SULFATES [J].
VOLLHARDT, D ;
CZICHOCKI, G ;
RUDERT, R .
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 1993, 76 :217-225
[35]   Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection [J].
Xu, YH ;
Szoka, FC .
BIOCHEMISTRY, 1996, 35 (18) :5616-5623
[36]   CHOLESTEROL AND THE CELL-MEMBRANE [J].
YEAGLE, PL .
BIOCHIMICA ET BIOPHYSICA ACTA, 1985, 822 (3-4) :267-287
[37]   The lower-generation polypropylenimine dendrimers are effective gene-transfer agents [J].
Zinselmeyer, BH ;
Mackay, SP ;
Schatzlein, AG ;
Uchegbu, IF .
PHARMACEUTICAL RESEARCH, 2002, 19 (07) :960-967