CD36 may determine our desire for dietary fats

被引：66

作者：

Abumrad, NA ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Med, Div Nutr Sci, St Louis, MO 63110 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2005年 / 115卷 / 11期

关键词：

D O I：

10.1172/JCI26955

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

There is a strong link between high fat intake and obesity. In addition to its high caloric density, dietary fat has a hyperphagic effect, in part as a result of its high palatability. The recent identification by Laugerette et al. of CD36 as a taste receptor for fatty acids provides insight into the molecular basis of our preference for fat (see the related article beginning on page 3177). As we gain more information regarding the function of this receptor, we may be able to devise better strategies to address the addictive potential of dietary fat.

引用

页码：2965 / 2967

页数：3

共 24 条

[1]

ABUMRAD NA, 1993, J BIOL CHEM, V268, P17665

[2] FoxO1 stimulates fatty acid uptake and oxidation in muscle cells through CD36-dependent and -independent mechanisms [J].

Bastie, CC ;

Nahlé, Z ;

McLoughlin, T ;

Esser, K ;

Zhang, WW ;

Unterman, T ;

Abumrad, NA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (14) :14222-14229

[3] Fatty acids, triglycerides, and glucose metabolism: recent insights from knockout mice [J].

Chen, HC ;

Farese, RV .

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2002, 5 (04) :359-363

[4] Sensory experience of food and obesity: a positron emission tomography study of the brain regions affected by tasting a liquid meal after a prolonged fast [J].

DelParigi, A ;

Chen, KW ;

Salbe, AD ;

Reiman, EM ;

Tataranni, PA .

NEUROIMAGE, 2005, 24 (02) :436-443

[5] CD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the blood [J].

Drover, VA ;

Ajmal, M ;

Nassir, F ;

Davidson, NO ;

Nauli, AM ;

Sahoo, D ;

Tso, P ;

Abumrad, NA .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (05) :1290-1297

[6] The impact of overexpression and deficiency of fatty acid translocase (FAT)/CD36 [J].

Febbraio, M ;

Guy, E ;

Coburn, C ;

Knapp, FF ;

Beets, AL ;

Abumrad, NA ;

Silverstein, RL .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2002, 239 (1-2) :193-197

[7]

Fukuwatari T, 1997, FEBS LETT, V414, P461, DOI 10.1016/S0014-5793(97)01055-7

[8] Fatty acid modulation of K+ channels in taste receptor cells: Gustatory cues for dietary fat [J].

Gilbertson, TA ;

Fontenot, DT ;

Liu, LD ;

Zhang, H ;

Monroe, WT .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1997, 272 (04) :C1203-C1210

[9] Fatty acid transport across membranes: Relevance to nutrition and metabolic pathology [J].

Hajri, T ;

Abumrad, NA .

ANNUAL REVIEW OF NUTRITION, 2002, 22 :383-415

[10] MEMBRANE GLYCOPROTEIN-IV (CD36) IS PHYSICALLY ASSOCIATED WITH THE FYN, LYN, AND YES PROTEIN-TYROSINE KINASES IN HUMAN PLATELETS [J].

HUANG, MM ;

BOLEN, JB ;

BARNWELL, JW ;

SHATTIL, SJ ;

BRUGGE, JS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (17) :7844-7848

← 1 2 3 →