Slipping through the door: HIV entry into the nucleus

被引：96

作者：

Sherman, MP

Greene, WC

机构：

[1] Gladstone Inst Virol & Immunol, San Francisco, CA 94141 USA

[2] Univ Calif San Francisco, Dept Med, San Francisco, CA 94123 USA

[3] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94123 USA

来源：

MICROBES AND INFECTION | 2002年 / 4卷 / 01期

关键词：

HIV nuclear import; preintegration complex;

D O I：

10.1016/S1286-4579(01)01511-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HIV infection of non-dividing cellular targets like macrophages requires successful passage of the viral preintegration complex (PIC) across an intact nuclear envelope. Unique but redundant nuclear import signals reside within the HIV integrase, matrix, and Vpr proteins as well as the 'DNA flap'; these signals appear to facilitate PIC transport through the limiting nuclear pores. We discuss recent studies that have advanced our understanding of this key step in the HIV life cycle. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All lights reserved.

引用

收藏

页码：67 / 73

页数：7

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