Highly regio- and stereo-selective alkylsubstitution with copper reagents for the construction of chiral trifluoromethylated quaternary carbon centres

被引:24
作者
Hiraoka, S [1 ]
Yamazaki, T [1 ]
Kitazume, T [1 ]
机构
[1] TOKYO INST TECHNOL,DEPT BIOENGN,MIDORI KU,YOKOHAMA,KANAGAWA 226,JAPAN
关键词
D O I
10.1039/a703223d
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A new route for the asymmetric construction of quaternary carbon centres containing a trifluoromethyl group has been established using a highly regio-and stereo-selective S(N)2' reaction of organocopper and organocuprate reagents with allylic mesylates 4 and 8.
引用
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页码:1497 / 1498
页数:2
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