Tissue-specific effect of age and caloric restriction diet on mitochondrial DNA content

被引：23

作者：

Cassano, P.

Sciancalepore, A. G.

Lezza, A. M. S.

Leeuwenburgh, C.

Cantatore, P.

Gadaleta, M. N.

机构：

[1] Univ Bari, Dept Biochem & Mol Biol, I-70125 Bari, Italy

[2] Univ Florida, Coll Med, Dept Aging & Geriatr Res, Biochem Aging Lab, Gainesville, FL USA

[3] CNR, Inst Biomembranes & Bioenerget, I-70126 Bari, Italy

来源：

REJUVENATION RESEARCH | 2006年 / 9卷 / 02期

关键词：

D O I：

10.1089/rej.2006.9.211

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The effect of age and caloric-restriction (CR) diet on mitochondrial DNA (mtDNA) content in different rat tissues was investigated. A decrease of the mtDNA content occurs with aging in liver and soleus muscle, whereas there is no age-related significant change of mtDNA content in brain. CR fully reverses the age-dependent loss of mtDNA in liver and soleus, whereas it results in a significant increase of mtDNA amount above the value of aged ad libitum fed rats in brain. These results further support the tissue-specific effect of CR, likely because of the different dependence of tissues on external nutrient uptake.

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收藏

页码：211 / 214

页数：4

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