Structural and signalling molecules come together at tight junctions

被引：259

作者：

Tsukita, S ^{[1
]}

Furuse, M ^{[1
]}

Itoh, M ^{[1
]}

机构：

[1] Kyoto Univ, Fac Med, Dept Cell Biol, Sakyo Ku, Kyoto 606, Japan

来源：

CURRENT OPINION IN CELL BIOLOGY | 1999年 / 11卷 / 05期

关键词：

D O I：

10.1016/S0955-0674(99)00016-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tight junctions (TJs) have been suggested to act both as barriers and fences, but lack of information on the constituents of TJ strands has hampered the direct assessment of these functions. Over the past year, our understanding of the molecular architecture of TJ strands has increased markedly and we are ready to experimentally examine how TJs are involved in their dual functions.

引用

页码：628 / 633

页数：6

共 55 条

[31] Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction [J].

Mandai, K ;

Nakanishi, H ;

Satoh, A ;

Obaishi, H ;

Wada, M ;

Nishioka, H ;

Itoh, M ;

Mizoguchi, A ;

Aoki, T ;

Fujimoto, T ;

Matsuda, Y ;

Tsukita, S ;

Takai, Y .

JOURNAL OF CELL BIOLOGY, 1997, 139 (02) :517-528

[32] Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration [J].

Martìn-Padura, I ;

Lostaglio, S ;

Schneemann, M ;

Williams, L ;

Romano, M ;

Fruscella, P ;

Panzeri, C ;

Stoppacciaro, A ;

Ruco, L ;

Villa, A ;

Simmons, D ;

Dejana, E .

JOURNAL OF CELL BIOLOGY, 1998, 142 (01) :117-127

[33]

Matter K, 1999, INT REV CYTOL, V186, P117

[34] Molecular architecture of tight junctions [J].

Mitic, LL ;

Anderson, JM .

ANNUAL REVIEW OF PHYSIOLOGY, 1998, 60 :121-142

[35] Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands [J].

Morita, K ;

Furuse, M ;

Fujimoto, K ;

Tsukita, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (02) :511-516

[36] Claudin-11/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testis [J].

Morita, K ;

Sasaki, H ;

Fujimoto, K ;

Furuse, M ;

Tsukita, S .

JOURNAL OF CELL BIOLOGY, 1999, 145 (03) :579-588

[37] Occludin is concentrated at tight junctions of mouse/rat but not human guinea pig Sertoli cells in testes [J].

Moroi, S ;

Saitou, M ;

Fujimoto, K ;

Sakakibara, A ;

Furuse, M ;

Yoshida, O ;

Tsukita, S .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1998, 274 (06) :C1708-C1717

[38] PDZ domains: Targeting signalling molecules to sub-membranous sites [J].

Ponting, CP ;

Phillips, C ;

Davies, KE ;

Blake, DJ .

BIOESSAYS, 1997, 19 (06) :469-479

[39] Involvement of Gαi2 in the maintenance and biogenesis of epithelial cell tight junctions [J].

Saha, C ;

Nigam, SK ;

Denker, BM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (34) :21629-21633

[40] Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions [J].

Saitou, M ;

Fujimoto, K ;

Doi, Y ;

Itoh, M ;

Fujimoto, T ;

Furuse, M ;

Takano, H ;

Noda, T ;

Tsukita, S .

JOURNAL OF CELL BIOLOGY, 1998, 141 (02) :397-408

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