Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study

被引：370

作者：

Michaud, Dominique S. ^{[1
,2
]}

Izard, Jacques ^{[3
,4
]}

Wilhelm-Benartzi, Charlotte S. ^{[2
,5
]}

You, Doo-Ho ^{[3
]}

Grote, Verena A. ^{[6
]}

Tjonneland, Anne ^{[7
]}

Dahm, Christina C. ^{[8
,9
]}

Overvad, Kim ^{[8
]}

Jenab, Mazda ^{[10
]}

Fedirko, Veronika ^{[10
]}

Boutron-Ruault, Marie Christine ^{[11
,12
]}

Clavel-Chapelon, Franoise ^{[11
,12
]}

Racine, Antoine ^{[11
,12
]}

Kaaks, Rudolf ^{[6
]}

Boeing, Heiner ^{[13
]}

Foerster, Jana ^{[13
]}

Trichopoulou, Antonia ^{[14
,15
]}

Lagiou, Pagona ^{[14
,16
,17
]}

Trichopoulos, Dimitrios ^{[16
,17
]}

Sacerdote, Carlotta ^{[18
,19
]}

Sieri, Sabina ^{[20
]}

Palli, Domenico ^{[21
]}

Tumino, Rosario ^{[22
,23
]}

Panico, Salvatore ^{[24
]}

Siersema, Peter D. ^{[25
]}

Peeters, Petra H. M. ^{[26
]}

Lund, Eiliv ^{[27
]}

Barricarte, Aurelio ^{[28
,29
]}

Huerta, Jose-Maria ^{[29
,30
]}

Molina-Montes, Esther ^{[29
,31
]}

Dorronsoro, Miren ^{[32
]}

Ramon Quiros, J. ^{[33
]}

Duell, Eric J. ^{[34
]}

Ye, Weimin ^{[35
,36
]}

Sund, Malin ^{[37
,38
,39
]}

Lindkvist, Bjorn ^{[40
]}

Johansen, Dorthe ^{[41
]}

Khaw, Kay-Tee ^{[42
]}

Wareham, Nick ^{[43
]}

Travis, Ruth C. ^{[44
]}

Vineis, Paolo ^{[2
]}

Bueno-de-Mesquita, H. Bas ^{[25
,45
]}

Riboli, Elio ^{[2
]}

机构：

[1] Brown Univ, Div Biol & Med, Dept Epidemiol, Providence, RI 02912 USA

[2] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London, England

[3] Forsyth Inst, Dept Mol Genet, Cambridge, MA USA

[4] Harvard Univ, Sch Dent Med, Dept Oral Med Infect & Immun, Boston, MA 02115 USA

[5] Univ London Imperial Coll Sci Technol & Med, London, England

[6] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[7] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[8] Aarhus Univ, Dept Epidemiol, Sch Publ Hlth, Aarhus, Denmark

[9] Aarhus Univ Hosp, Dept Cardiol, DK-8000 Aarhus, Denmark

[10] Int Agcy Res Canc IARC WHO, Lyon, France

[11] Inst Gustave Roussy, INSERM, Ctr Res Epidemiol & Populat Hlth, U1018, F-94805 Villejuif, France

[12] Paris South Univ, UMRS 1018, Villejuif, France

[13] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

[14] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Food & Nutr Policies, GR-11527 Athens, Greece

[15] Hellen Hlth Fdn, Athens, Greece

[16] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[17] Acad Athens, Bur Epidemiol Res, Athens, Greece

[18] Ctr Canc Prevent CPO Piemonte, Turin, Italy

[19] Human Genet Fdn HuGeF, Turin, Italy

[20] Fdn IRCCS Ist Nazl Tumori, Nutr Epidemiol Unit, Dept Prevent & Predict Med, Milan, Italy

[21] ISPO Canc Res & Prevent Inst, Mol & Nutr Epidemiol Unit, Florence, Italy

[22] Civile MP Arezzo Hosp, Canc Registry, Ragusa, Italy

[23] Civile MP Arezzo Hosp, Histopathol Unit, Ragusa, Italy

[24] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[25] Univ Med Ctr Utrecht, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[26] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[27] Univ Tromso, Inst Community Med, Tromso, Norway

[28] Publ Hlth Inst Navarra, Pamplona, Spain

[29] CIBER Epidemiol & Salud Publ CIBERESP, Pamplona, Spain

[30] Murcia Reg Hlth Author, Dept Epidemiol, Murcia, Spain

[31] Andalusian Sch Publ Hlth, Granada, Spain

[32] Basque Reg Hlth Dept, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[33] Hlth & Hlth Care Serv Council, Publ Hlth & Participat Directorate, Asturias, Spain

[34] Catalan Inst Oncol ICO IDIBELL, Canc Epidemiol Res Programme, Unit Nutr Environm & Canc, Barcelona, Spain

[35] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[36] Umea Univ, Med Biobank, Umea, Sweden

[37] Umea Univ, Dept Surg & Perioperat Sci, Umea, Sweden

[38] Umea Univ, Dept Surg, Umea, Sweden

[39] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[40] Univ Gothenburg, Sahlgrenska Acad, Inst Med, Gothenburg, Sweden

[41] Skane Univ Hosp, SUS, Dept Surg, Malmo, Sweden

[42] Univ Cambridge, Sch Clin Med, Cambridge, England

[43] MRC, Epidemiol Unit, Cambridge, England

[44] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, Oxford, England

[45] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

来源：

GUT | 2013年 / 62卷 / 12期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

Pancreatic Cancer; Epidemiology; Bacterial Pathogenesis; LINKED-IMMUNOSORBENT-ASSAY; PORPHYROMONAS-GINGIVALIS; PERIODONTAL-DISEASE; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; RESPONSES; MICROBIOTA; ABO; PHAGOCYTOSIS; ASSOCIATION; EXPLORATION;

D O I：

10.1136/gutjnl-2012-303006

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Objective Examine the relationship between antibodies to 25 oral bacteria and pancreatic cancer risk in a prospective cohort study. Design We measured antibodies to oral bacteria in prediagnosis blood samples from 405 pancreatic cancer cases and 416 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition study. Analyses were conducted using conditional logistic regression and additionally adjusted for smoking status and body mass index. Results Individuals with high levels of antibodies against Porphyromonas gingivalis ATTC 53978, a pathogenic periodontal bacteria, had a twofold higher risk of pancreatic cancer than individuals with lower levels of these antibodies (OR 2.14; 95% CI 1.05 to 4.36; >200ng/ml vs 200ng/ml). To explore the association with commensal (non-pathogenic) oral bacteria, we performed a cluster analysis and identified two groups of individuals, based on their antibody profiles. A cluster with overall higher levels of antibodies had a 45% lower risk of pancreatic cancer than a cluster with overall lower levels of antibodies (OR 0.55; 95% CI 0.36 to 0.83). Conclusions Periodontal disease might increase the risk for pancreatic cancer. Moreover, increased levels of antibodies against specific commensal oral bacteria, which can inhibit growth of pathogenic bacteria, might reduce the risk of pancreatic cancer. Studies are needed to determine whether oral bacteria have direct effects on pancreatic cancer pathogenesis or serve as markers of the immune response.

引用

页码：1764 / 1770

页数：7

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